A novel germ-line JK transcript starting immediately upstream of JK1.

نویسندگان

  • L Leclercq
  • P Butkeraitis
  • M Reth
چکیده

Germ-line transcripts of the immunoglobulin (Ig) and T cell receptor loci are thought to be involved in the control of V gene rearrangement by rendering these loci accessible to the recombinases. We have analyzed the transcriptional activity of germ-line K alleles in two bone marrow-derived Abelson-murine leukemia virus transformed pre-B cells: 300-19, a null cell line, and P8 a mu-producing line. We found a novel germ-line JK transcript starting immediately upstream of JK1 and spliced to CK. The potential role of this transcript in the opening of the Ig K locus as well as in the ordered usage of JK segments is discussed.

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عنوان ژورنال:
  • Nucleic acids research

دوره 17 17  شماره 

صفحات  -

تاریخ انتشار 1989